Does HBV Infection Increase Risk of Endometrial Carcinoma?


Objective: Connections between chronic inflammation and tumor development and progression are nowgenerally accepted. Recent evidence indicates that hepatitis B is associated with several types of cancer, butwhether endometrial carcinoma (EC) is included has not been reported.
Methods: We analyzed HBV serummarker status in 398 patients with endometrial cancer, comparing them to 788 control women undergoing healthexamination.
Results: The total prevalence of HBsAg tested positive in cancer group was significantly higherthan the control group (12.8% vs 6.0%, P=0.001), while positive HBsAb was significantly lower (41.2% vs 68.5%,P=0.001). Hepatitis B carriers in endometrial cancer group were also more frequent than in the control group(9.3% vs 5.5%, P=0.013). Interestingly, in the endometrial cancer group, 147 cases were HBV serum markernegative, which was also higher than in the control group (36.9% vs 15.6%, P=0.001).
Conclusion: There maybe a correlation between HBV infection and endometrial carcinoma.