Factors for Postoperative Gallstone Occurrence in Patients with Gastric Cancer: a Meta-analysis


Objective: To evaluate risk factors for gallstones after gastrectomy.
Methods: To identify documents publishedfrom 1990 to 2011 the Pubmed, Cochrane Library, Springer Link, CBM and WanFang databases were searchedand a meta-analysis was performed with RevMan 5.2 software for odds ratios and 95%CIs.
Results: Fifteenstudies were selected for the meta-analysis. The pooled ORs [95%CIs] were 0.56 [0.43, 0.73], (P<0.0001) fordigestive tract reconstruction, 0.80 [0.54, 1.17], (P=0.25) for pylorus preservation, 0.33[0.15, 0.75], (P=0.008) forresection scope of stomach, 0.33 [0.15, 0.75], (P=0.008) for lymphadenectomy, and 0.13 [0.05, 0.33], (P<0.0001)for vagotomy.
Conclusions: Digestive tract physical reconstruction and vagus nerve preservation can reducethe morbidity of gallstones after gastrectomy. Total gastrectomy can add to the morbidity of galltones as doesincreasing the degree of lymph node dissection. There was no significant difference in gallstones with or withoutpylorus preservation.