In Morocco, breast cancer is the most prevalent cancer in women and a major public health problem. SeveralMoroccan studies have focused on studying this disease, but more are needed, especially at the genetic andmolecular levels. It is therefore interesting to establish the genetic and molecular profile of Moroccan patientswith breast cancer. In this paper, we will highlight some pertinent hypotheses that may enhance breast cancercare in Moroccan patients. This review will give a precise description of breast cancer in Morocco and proposesome new markers for detection and prediction of breast cancer prognosis.