Influence of Adipocytokines and Periprostatic Adiposity Measurement Parameters on Prostate Cancer Aggressiveness

Background: The relationship between obesity and prostate cancer aggressiveness is controversial in recentstudies, partly because BMI is the only generally applied marker of obesity. Our study aimed at evaluatingthe correlation of periprostatic fat (PF) on magnatic resonance imaging (MRI) and adipocytokines withprostate cancer aggressiveness. Patients and method: A total of 184 patients who underwent radical retropubicprostatectomy (RRP) were analyzed retrospectively; different fat measurements on MRI slices and levels ofadipocytokines were compared with the clinical and pathologic factors using SSPS ver.13.0.
Result: The PF ratesshowed a statistically significant variation (p=0.019, 0.025) among groups, that is to say, more adipose tissue wasdistributed in periprostatic areas of high risk patients. Logistic regression analysis adjusted for age revealed astatistically association between the PF, the ratio and the risk of having high-risk disease (p=0.031, 0.024). Thelevels of IL-6, leptin and c-reactive protein (CRP) significantly increased with the aggressiveness of prostate cancer,and also with PF and its ratio. The strongest correlation was seen between IL-6 and PF (Pearson r coefficient=0.67,P<0.001). No association was observed between adipocytokines and BMI.
Conclusion: Periprostatic adipositynot only affects prostate cancer aggressiveness, but also influences the secretion of adipocytokines. IL-6, PF andCRP have promoting effects on progression of prostate cancer.