Anticancer Therapy for Breast Cancer Patients with Skin Metastases Refractory to Conventional Treatments

Skin metastases of breast cancer are usually late events in the course of tumor progression and signify apoor prognosis. They may remain as a therapeutic challenge especially after failure of standard treatments.Topical interventions, together with or without radiotherapy, may only palliate the symptoms temporarily.However, there may be alternative treatment modalities for unresectable breast cancer skin metastases resistantto chemotherapy and radiotherapy. There are various genetic alterations in tumors and therapeutic potential ofexpression patterns for factors like epidermal growth factor receptor may have important clinical implications incase of disease refractory to the conventional treatments. Here, we clarified the therapeutic options and geneticalterations in skin metastatic breast cancer patients refractory to standard chemotherapeutics.