Gonadotrophin Releasing Hormone Analogues for Ovarian Function Preservation in Young Females Undergoing Chemotherapy

Chemotherapy has significantly improved the prognosis of cancer patients with various malignancies. However,female patients, especially those whoich are premenopausal, suffer from significant chemotherapy induced ovarianfunction impairment, which decreases their quality of life. Many new techniques for ovarian preservation havebeen established in recent years. Although the use of gonadotrophin releasing hormone analogues (GnRHa)for this purpose is not a new concept, its effectiveness in protection of ovarian function is still debatable. Thisarticle deals with studies and metaanalyses which have been undertaken in the past, demonstrating the impactof GnRHa in ovarian function preservation, and whether their use can be implemented in routine practice.