Background: Trace elements are major components of biological structures; however, excessive levels ofthese elements can be toxic. Materials and Methods: In the present study, serum levels of trace elements weremeasured in 30 patients with newly diagnosed as prostate cancer and 32 healthy volunteer by using furnaceatomic absorption spectrophotometry. Results: It was found that there was an increase in serum levels of Co,Cu, Mg and Pb (p<0.05), whereas a decrease in serum levels of Fe, Mn, and Zn levels in patients with prostatecancer (p<0.05). Conclusions: These changes may be important in the pathogenesis of prostate cancers; however,further prospective studies are needed to identify relationships between prostate cancer and trace elements.