Genotype CC of rs1800947 in the C-Reactive Protein Gene May Increase Susceptibility to Colorectal Cancer: a Meta-Analysis

Background: Single nucleotide polymorphisms of C-reactive protein (CRP) have been shown to be relatedto circulating CRP level, risk and prognosis in cancer patients. However, accumulating evidence of rs1800947involvement in risk of cancer is inconsistent. Thus, a meta-analysis was performed to obtain a more preciserelationship. Materials and
Methods: The pooled odds ratio (OR) and its 95% confidence interval were assessedin 10 eligible articles with 12 studies containing 5,601 cancer cases and 8,669 cancer-free controls.
Results: Nosignificant association was observed overall and in subgroups in comparison of genotype GC vs GG (PH=0.847,OR=0.939, 95%CI=0.810-1.087), GC/CC vs GG (PH=0.941, OR=1.021, 95%CI=0.901-1.157) and allele C vs G(PH=0.933, OR=1.026, 95%CI=0.909-1.159). However, statistically significance was evident in comparison ofgenotype CC vs GG in cancer risk (PH=0.586, OR=2.854, 95%CI= 1.413-5.763), especially in colorectal cancer(PH=0.481, OR=4.527, 95%CI= 1.664- 12.315).
Conclusions: Genotype CC of rs1800947 in the CRP gene isstrongly associated with increased cancer risk, particularly in colorectal cancer.