Drainage Alone or Combined with Anti-tumor Therapy for Treatment of Obstructive Jaundice Caused by Recurrence and Metastasis after Primary Tumor Resection

Aim: To compare drainage alone or combined with anti-tumor therapy for treatment of obstructive jaundicecaused by recurrence and metastasis after primary tumor resection. Materials and
Methods: We collect 42 patientswith obstructive jaundice caused by recurrence and metastasis after tumor resection from January 2008 - August2012, for which percutaneous transhepatic catheter drainage (pTCD)/ percutaneous transhepatic biliary stenting(pTBS) were performed. In 25 patients drainage was combined with anti-tumor treatment, antineoplastic therapyincluding intra/postprodure local treatment and postoperative systemic chemotherapy, the other 17 undergoingdrainage only. We assessed the two kinds of treatment with regard to patient prognosis.
Results: Both treatmentsdemonstrated good effects in reducing bilirubin levels in the short term and promoting liver function. The timeto reobstruction was 125 days in the combined group and 89 days in the drainage only group; the mean survivaltimes were 185 and 128 days, the differences being significant.
Conclusions: Interventional drainage in thetreatment of the obstructive jaundice caused by recurrence and metastasis after tumor resection can decreasebilirubin level quickly in a short term and promote the liver function recovery. Combined treatment prolongsthe survival time and period before reobstruction as compared to drainage only.