Objectives: The aim of this study was to describe and analyze the incidence and mortality of female breastcancer in Jiangsu Province of China. Methods: Incidence and mortality data for female breast cancer andcorresponding population statistics from eligible cancer registries in Jiangsu from 2006 to 2010 were collected andanalyzed. Crude rates, age-specific rates and age-standardized rates of incidence and mortality were calculated,and annual present changes (APCs) were estimated to describe the time trends. Results: From 2006 to 2010, 11,013new cases and 3,068 deaths of female breast cancer were identified in selected cancer registry areas of Jiangsu.The annual average crude incidence and age-standardized incidence by world population (ASW) were 25.2/ and17.9/100,000 respectively. The annual average crude and ASW for mortality rates were 7.03/ and 4.81/100,000.The incidence was higher in urban areas than that in rural areas, and this was consistent in all age groups. Nosignificant difference was observed in mortality between urban and rural areas. Two peaks were observed whenlooking at age-specific rates, one at 50-59 years and another at over 85 years. During the 5 years, incidence andmortality increased with APCs of 4.47% and 6.89%, respectively. Compared to the national level, Jiangsu isan area with relatively low risk of female breast cancer. Conclusion: Breast cancer has become a main publichealth problem among Chinese females. More prevention and control activities should be conducted to reducethe burden of this disease, even in relatively low risk areas like Jiangsu.