The G801A Polymorphism in the CXCL12 Gene and Risk of Breast Carcinoma: Evidence from a Meta-Analysis Including 2,931 Subjects

More and more evidence indicates that the G801A polymorphism in the CXCL12 gene might be associatedwith susceptibility to breast carcinoma in humans being. However, individually published results havebeen inconsistent. The purpose of this meta-analysis was to investigate the association between the G801Apolymorphism in the CXCL12 gene and breast carcinoma risk. A complete search strategy was done by theelectronic databases including PubMed and Chinese Biomedical Literature Database. A meta-analysis includingseven individual studies was carried out in order to explore the association between the G801A polymorphism inthe CXCL12 gene polymorphisms and breast carcinoma. The pooled odds ratios (ORs) and their corresponding95% confidence intervals (95%CIs) between the G801A polymorphism in the CXCL12 gene and breast carcinomarisk were assessed by the random-effects model. A significant relationship between the G801A polymorphism inthe CXCL12 gene and breast carcinoma was discovered in an allelic genetic model (OR: 1.214, 95%CI: 1.085-1.358, p=0.001), a homozygote model (OR: 1.663, 95%CI: 1.240-2.232, p=0.001), a heterozygote model (OR:1.392, 95%CI: 1.190-1.629, p=0.000), a recessive genetic model (OR: 1.407, 95%CI: 1.060-1.868, p=0.018) and adominant genetic model (OR: 1.427, 95%CI: 1.228-1.659, p=0.000). On sub-group analysis based on ethnicity,significance was observed between the European group and the mixed group. A significant relationship wasfound between the G801A polymorphism in the CXCL12 gene and breast carcinoma risk. Individuals with theA allele of the G801A polymorphism in the CXCL12 gene are under a higher risk for breast carcinoma.