Incidence and Clinical Outcomes of Non-endometrioid Carcinoma of Endometrium: Siriraj Hospital Experience

Background: To study the incidence of non-endometrioid carcinoma of endometrium and compare the clinicalcharacteristics and treatment outcomes with endometrioid carcinoma patients. Materials and
Methods: Thisstudy included 236 patients with endometrial carcinoma at Siriraj Hospital whom were diagnosed and treatedfrom 2003 through 2006. The clinical characteristics, pathological features, treatment and clinical outcomeswere collected from the medical records. The 5-year survival was calculated according to 2009 FIGO staging.
Results: Non-endometrioid carcinoma of endometrium accounted for 10.2% of all endometrial carcinomas(24/236 patients). The 5 -year survival rate was significantly lower in the non-endometrioid group compared tothe endometrioid group (77.3% vs 96%, p<0.001) and clinical data pointed to greater malignancy.
Conclusions:Non-endometrioid carcinoma of endometrium is relative rare but is more aggressive, has more distant metastasisat diagnosis with a worse survival rate than endometrioid carcinoma. Only patients in stage IA with no residualdisease on a hysterectomy specimen may not need adjuvant treatment.