Application of Tumor Markers SCC-Ag, CEA, and TPA in Patients with Cervical Precancerous Lesions

Background: To determine the potential clinical utility of tumor markers CEA, TPA, and SCC-Ag for earlydetection of cervical precancerous lesions. Materials and
Methods: A case-control study was carried out on120 women (46 patients with histologically confirmed cervical precancerous lesions and 74 healthy controls).The significance of serum selected tumor markers in early detection of cervical intraepithelial neoplasia (CIN)were assessed.
Results: Of the case group, the rates of CIN I, II, III, was 69.6%, 23.9%, and 6.5%, respectively.According to the manufacturer’s cut-off values of 2ng/ml, 5ng/ml, and 70 U/ml for SCC-Ag, CEA and TPA tests,in that order, SCC-Ag test had a sensitivity of 13%, but CEA and TPA tests could not distinguish between caseand control groups. The diagnostic sensitivities were highest at cut-off values of 0.55 ng/ml for SCC-Ag, 2.6ng/ml for CEA, and 25.5 U/ml for TPA which were 93%, 61%, and 50%, respectively. However, the area under thereceiver operating characteristic curve was the largest for SCC-Ag (0.95 vs. 0.61 and 0.60 for CEA and TPA,respectively). Moreover, there was a highly significant direct correlation between SCC-Ag concentration and thedegree of cervical precancerous lesions (r=0.847, p<0.001).
Conclusions: The new cutoff of 0.5 for SCC-Ag testmight be useful as a tumor marker in Iranian patients with CIN and it needs to be more evaluated by studieswith larger populationa.