Are Bladder Neoplasms More Aggresive in Patients with a Smoking-related Second Malignancy?

Background: Relationships between smoking and bladder neoplasms, one of the common malignancies, arewell-known. Different smoking-related malignancies may occur together. In this study, we evaluated the stageand grade of bladder neoplasms in patients also featuring lung or larynx cancer. Materials and
Methods: FromJanuary 2006 to February 2012, patients who underwent surgery for bladder neoplasms in our clinic werescreened retrospectively. In the evaluation, 5 patients had larynx cancer and 20 patients have lung cancer inaddition, all having been smoking for a long time. The bladder tumor stage and grade were investigated in these25 cases.
Results: Mean age of patients was 66.8 (49-78). In the evaulation, all of 5 patients who had larnyx canceralso had high grade urothelial cancer. One had T2 urothelial, and 3 T1 urothelial cancer. In the same way, allof the 20 patients with lung cancer also have high grade urothelial cancer, three T2, and 13 T1. Bladder cancerstage and grade were determined to be significantly increased in patients with concomitant bladder and lungor larynx cancer.
Conclusions: In the patients who have smoking releated second malignancy, bladder cancerprognosis appears more aggressive. We now need a larger series and multi-center studies for understandingrelevant pathophysiology.