Objectives: The identification of cutaneous T cell lymphoma (CTCL) biomarkers may serve as a predictor of disease progression and treatment response. The aim of this study was to map potential biomarkers in CTCL plasma. Design and Methods: Plasma metabolic perturbations between CTCL cases and healthy individuals were investigated using metabolomics and ultrahigh performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS). Results: Principal component analysis (PCA) of the spectra showedclear metabolic changes between the two groups. Thirty six potential biomarkers associated with CTCL were found. Conclusions: Based on PCA, several biomarkers were determined and further identified by LC/MS/MS analysis. All of these could be potential early markers of CTCL. In addition, we established that heparin as a nticoagulant has better pre-treatment results than EDTA with the UHPLC-QTOF/MS appraoch.
(2014). Metabolomics Investigation of Cutaneous T Cell Lymphoma Based on UHPLC-QTOF/MS. Asian Pacific Journal of Cancer Prevention, 15(13), 5417-5421.
MLA
. "Metabolomics Investigation of Cutaneous T Cell Lymphoma Based on UHPLC-QTOF/MS". Asian Pacific Journal of Cancer Prevention, 15, 13, 2014, 5417-5421.
HARVARD
(2014). 'Metabolomics Investigation of Cutaneous T Cell Lymphoma Based on UHPLC-QTOF/MS', Asian Pacific Journal of Cancer Prevention, 15(13), pp. 5417-5421.
VANCOUVER
Metabolomics Investigation of Cutaneous T Cell Lymphoma Based on UHPLC-QTOF/MS. Asian Pacific Journal of Cancer Prevention, 2014; 15(13): 5417-5421.