The ‘Karachi Cancer Registry’ (KCR) is the first population-based cancer registry in Pakistan. The Government of Sindhestablished it in January 1995, in collaboration with the Unit of Descriptive Epidemiology, International Agency for Researchon Cancer (IARC) of the World Health Organisation (WHO). The registry has completed 5 years of data collection.Previous to this there has been no cancer incidence data available from anywhere in Pakistan over the last five decades.Sporadic relative frequency information from hospitals, including the Jinnah Postgraduate Medical Centre (JPMC) and anetwork of hospital registries coordinated by the Pakistan Medical and Research Council (PMRC).1,2,3 had been available,with associated selection biases.The registry publishes annual reports and data were published earlier this year, with the help of IARC4.