Impact of Caspase-8 (CASP8) -652 6N Del and D302H Polymorphisms on Prostate Cancer in Different Ethnic Groups

Background: Despite evidence suggesting roles for caspase-8 (CASP8) -652 6N del and D302H polymorphismsin prostate cancer (PCa), the association of these polymorphisms with PCa risk remains inconclusive. Therefore,a meta-analysis was performed to more precisely estimate the association of CASP8 -652 6N del and D302Hpolymorphisms with PCa susceptibility. Materials and
Methods: A comprehensive literature search was conductedto identify all case-control studies of CASP8 D302H and -652 6N del polymorphisms and PCa risk. Odds ratios(ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association and the precision ofthe estimate, respectively.
Results: Nine -625 6N del studies and 4 D302H studies were included. CASP8 -652 6Ndel and D302H polymorphisms were not significantly associated with PCa risk in the overall analyses. However,in the subgroup analysis stratified by ethnicity, -625 6N del was significantly associated with PCa risk in theEast Asian and Indian populations under the recessive model. Furthermore, the subgroup analysis stronglysuggested that D302H was associated with lower PCa risk in the Non-Indian population under the dominantmodel.
Conclusions: In our meta-analysis, ethnic-specific differences were evident in the association of CASP8-625 6N del and D302H polymorphisms with PCa risk.