Comprehensive Analysis of Temozolomide Treatment for Patients with Glioma

Background: This analysis was conducted to evaluate the efficacy and safety of temozolomide basedchemotherapy in treating patients with glioma.
Methods: Clinical studies evaluating the efficacy and safety oftemozolomide based regimens for patients with glioma were identified using a predefined search strategy. Pooledresponse rates (RRs) were calculated.
Results: In temozolomide based regimens, 5 clinical studies including 152patients with advanced glioma were considered eligible for inclusion. Four clinical studies included temozolomide.Systematic analysis suggested that, in all patients, pooled CR was 21% (32/152) , and PR was 21% (32/152).Grade 3/4 toxicity included neutropenia, thrombocytopenia, and anemia. No grade 3 or 4 renal or liver toxicitywas observed. No treatment related death occurred with temozolomide based treatment.
Conclusion: Thissystematic analysis suggests that temozolomide based regimens are associated with mild response rate andacceptable toxicity for treatment of glioma patients.