Significant Association of Metabolic Indices, Lipid Profile, and Androgen Levels with Prostate Cancer

Objectives: To compare the metabolic indices, lipid profile, androgens, and prostate specific antigen betweenprostate cancer and BPH and between grades of prostate cancer in a cross-sectional study. Materials and
Methods:The study enrolled 95 cases of prostate cancer and 95 cases of benign prostatic hyperplasia (BPH). Prostate glandvolume was measured using transrectal ultrasound. We compared insulin, testosterone, dihydrotestosterone,prostate specific antigen levels and lipid profile between prostate cancer of different grades and BPH. Further,prostate cancer patients were classified into low grade and high grade. Unpaired t-test for normally distributedvariables and Man-Whitney U test for non-normal variables were used to assess differences.
Results: We foundthat prostate cancer patients had significantly higher levels of insulin, testosterone, PSA, cholesterol, triglycerides,low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) in comparison to their BPH counterparts.Higher levels of these parameters also correlated with a higher grade of the disease.
Conclusions: We concludethat higher levels of insulin, testosterone, PSA, and cholesterol correlate with a higher risk of prostate cancer,and also with a higher grade of the disease.