Easter Island is a small island of 180 km2, located 3,800 km from the Chilean coast and one of the mostisolated inhabited places in the world. Since the mid-twentieth century, it has been undergoing an epidemiologicaltransition in relation to the causes of death, from a predominance of infectious to non-communicable diseases(NCDs) such as cardiovascular ailments and cancer. The aim of this study is to describe the causes of death toEaster Island between 2000 and 2012, so the statistical records of Hanga Roa Hospital and death certificates werereviewed. The period under review of 13 years there was a total of 252 deaths, an average to 19.3 deaths per year.The most frequent causes of death found in the general population of Easter Island were cardiovascular diseases(25.4%), followed by neoplasms (23.4%), accidents (18.6%). Related to Rapa Nui people, cardiovascular andneoplastic diseases (both 26.7%) predominate, while in the population without belonging to the ethnic group themain causes were traumatic (25%) and cardiovascular (22.2%). Comparing the leading causes of death of EasterIsland with mainland Chile, it can be seen how they resemble. Taking the island death profile, it is necessary towork on public health strategies aimed to this, considering that some of the causes are completely preventable.