Purpose: Analysis of descriptive epidemiological characteristics of pancreatic cancer in Vojvodina, Serbia.Materials and Methods: The study covers population of Vojvodina in the period from 2000 to 2009. The methodused for data processing was the descriptive. The data, referring to a specified period of time, were analyzedfrom chronological and demographic aspects and according to histological diagnosis. Results: In the periodfrom 2000 to 2009, there were 2,108 registered cases of pancreatic cancer of which 1,886 had a fatal outcome.Standardized incidence rates varied between 5.7 and 9.1 per 100,000 population in males and between 4.2 and5.3 in females. Linear incidence trends in males in the specified period of time, based on crude (r=0.7883, p<0.05)and standardized (r=0,6373, p<0,05) incidence rates, demonstrated increase. Annual percent increase in thecrude incidence rate was 4.5% in males, and 2.8% in females. Age-standardized mortality rates varied between5.2 and 7.5 per 100,000 population in males and 3.6 and 4.7 in females. Linear mortality trends in males in thespecified period of time, based on crude (r=0.8795, p<0.05) and standardized (r=0.7669, p<0.05) mortality rates,also demonstrated annual percent increase. Conclusions: Data analysis shows unfavorable onco-epidemiologicalsituation related to pancreatic cancer in Vojvodina, in aspects of both incidence and mortality. Absence of primaryand secondary prevention does not allow medical institutions to successfully fight against this disease.