Immunohistochemical Expression of Cytokeratins and Epithelial Membrane Protein 2 in Nasopharyngeal Carcinoma and its Potential Implications


Background: Nasopharyngeal carcinoma (NPC) is an aggressive disease and tends to involve surroundingtissues, and biomarkers for better management are yet to be identified. Materials and
Methods: One hundredand fifty tissue samples with NPC diagnosis were were investigated using pan cytokeratin (CK) and epithelialmembrane protein 2 (EMP2) antibodies.
Results: Immunohistochemical expression of CK was identified in144/150 (96%) and of EMP2 in 120/150 (80%).
Conclusions: There is a high loss of EMP2 in NPC, especiallyhigh grade examples. Loss of CK expression is also linked to high grade NPC types.