DNA Repair Gene Polymorphisms Do Not Predict Response to Radiotherapy-Based Multimodality Treatment of Patients with Rectal Cancer: a Meta-analysis


Background: : A number of association studies have been carried out to investigate the relationship betweengenetic polymorphisms in DNA repair genes and response to radiotherapy-based multimodality treatment ofpatients with rectal cancer. However, their conclusions were inconsistent. The objective of the present study wasto assess the role of DNA repair gene genetic polymorphisms in predicting genetic biomarkers of the response inrectal cancer patients treated with neoadjuvant chemoradiation. Materials and
Methods: Studies were retrievedby searching the PubMed database, Cochrane Library, Embase, and ISI Web of Knowledge. We conducted ameta-analysis to evaluate the association between genetic polymorphisms and the response in rectal cancer treatedwith neoadjuvant chemoradiation by checking odds ratios (ORs) and 95% confidence intervals (CIs).
Results:Data were extracted from 5 clinical studies for this meta-analysis. The results showed that XRCC1 RS25487,XRCC1 RS179978, XRCC3 RS861539, ERCC1 RS11615 and ERCC2 RS13181 were not associated with theresponse in the radiotherapy-based multimodality treatment of patients with rectal cancer (p>0.05).
Conclusions:This study shows that DNA repair gene common genetic polymorphisms are not significantly correlated withthe radiotherapy-based multimodality treatment in rectal cancer patients.