Lack of Participation of the GSTM1 Polymorphism in Cervical Cancer Development in Northeast Thailand


The potential association between the GSTM1 deletion polymorphism and risk of cervical cancer wasinvestigated in Northeastern Thailand. DNA was extracted from buffy coat specimens of 198 patients withsquamous cell carcinoma of the cervix and 198 age-matched healthy controls. Genotyping of the GSTM1 wasconducted by using two PCR methods, a short- and a long-PCR. Distribution of the GSTM1 genotypes inbetween the cases and the controls was not significantly different (p>0.5 by χ2 test). The results suggest that theGSTM1 deletion polymorphism is not a risk factor for squamous cell carcinoma of the cervix in the northeastThai women.