Effects of Metformin on Cell Kinetic Parameters of MCF-7 Breast Cancer Cells in Vitro


In this study, the antiproliferative effects of the metformin was evaluated on MCF-7 Cells (human breastadenocarcinoma cell line). For this purpose cell kinetic parameters including cell proliferation assay, mitoticindex and labelling index analysis were used. 30 μM, 65 μM and 130 μM Metformin doses were applied to cellsfor 24, 48 and 72 hours. The results showed that there was a significant decrease in cell proliferation, mitoticindex and labelling index for all experimental groups (p<0.05) for all applications.