Utility of Peripheral Blood Parameters in Predicting Breast Cancer Risk


Purpose: We aimed to study the inflammatory parameters of complete blood count in breast cancer cases.Materials and
Methods: This retrospective study covered 178 breast cancer patients and 107 age and body massindex matched healthy women. Complete blood count parameters, neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and MPV/platelet were analyzed.
Results: The leukocyte, neutrophil and neutrophil/lymphocyte ratio were higher in the patient group (p values 0.001, 0.0001 and 0.0001, respectively) whilehaemoglobin and hematocrit were higher in the control group (p=0.0001 for both). Logistic regression analysisshowed that elevated neutrophils and platelet distribution width (PDW) (OR: 0.627, 95%CI: 0.508-0.774, p=0.001and OR: 1.191 95%CI: 1.057-1.342 p=0.003) were independent variables for predicting breast cancer. The cutoffvalue for the neutrophil/lymphocyte ratio was 2.56.
Conclusions: According to our study results, neutrophillevels as part of complete blood count may be used as an independent predictor of breast cancer risk.