RASSF1A Gene Methylation is Associated with Nasopharyngeal Carcinoma Risk in Chinese

In order to explore the association between RASSF1A methylation and nasopharyngeal carcinoma (NPC)risk of Chinese, we carried out a meta-analysis with searches of PubMed, Web of Science, ProQest and Medlinedatabases. Ultimately, 14 articles were identified and analysised using R Software (R version 3.1.2) includingmeta packages. Overall, we found a significant relationship between RASSF1A methylation and NPC risk (OR30.7; 95 % CI, 16.71~56.23; z=11.0591; p<0.0001) in a fixed effects model and (OR 32.1; 95% CI, 14.27~72.01;z=8.3984; p<0.0001) in a random effects model pooled. In tissue and NP brushings groups , similar results werefound. Hence, our study identified a strong association between RASSF1A methylation and NPC and highlighteda promising potential for RASSF1A methylation in NPC risk prediction of Chinese.