Role of CD10 Immunohistochemical Expression in Predicting Aggressive Behavior of Phylloides Tumors

Background: Phylloides tumors are rare breast neoplasms with a variable clinical course depending on thetumor category. Along with histologic features, the role of immunohistochemical staining has been studied inpredicting their behavior.
Objectives: Our aim was to evaluate the role of CD 10 immunohistochemical stainingin predicting survival, recurrence and metastasis in phylloides tumor. We also evaluated correlations of otherclinicopathological features with overall and disease-free survival. Materials and
Methods: CD10 expression wasstudied in 82 phylloides tumors divided into recurrent/metastatic and non-recurrent/non-metastatic cohorts. TheChi-square test was applied to determine the significance of differences in CD10 expression between outcomecohorts. Uni and multivariate survival analyses were also performed using log-rank test and Cox regression hazardmodels.
Results: All 3 metastatic cases, 5 out of 6 (83.3%) recurrent cases and 37out of 73 (50.7%) non-recurrentand non-metastatic cases expressed significant (2+ or 3+) staining for CD10. This expression significantly variedbetween outcome cohorts (p<0.03). Tumor category and histological features including mitotic count and necrosiscorrelated significantly with recurrence and metastasis. A significant decrease in overall and disease free survivalwas seen with CD10 positivity, malignant category, increased mitoses and necrosis. Neither CD10 expression norany other clinicopathologic feature proved to be an independent prognostic indicator in multivariate analysis.
Conclusions: CD10 immunohistochemical staining can be used as a predictive tool for phylloides tumor but thisexpression should be interpreted in conjunction with tumor category.