Changes of Plasma Tumor Necrosis Factor α and C-Reactive Protein Levels in Patients with Hypertension Accompanied by Impaired Glucose Tolerance and their Clinical Significance


Background: Chronic inflammation could affect the occurrence and development of malignant tumors. Toexplore the levels of tumor necrosis factor α (TNF-α) and C-reactive protein (CRP) in patients accompanied byimpaired glucose tolerance (IGT) and their clinical significance. Materials and
Methods: A total of 210 patientshospitalized in Affiliated Hospital of Taishan Medical University from Jun., 2013 to Dec., 2014 were selected,in which 92 cases were accompanied by IGT. Meanwhile, 80 randomly-selected healthy people by physicalexamination were as the control. The levels of routine biochemical indexes, plasma TNF-α and CRP in allsubjects were measured.
Results: Both systolic and diastolic pressures in hypertension group and hypertensionplus IGT group were significantly higher than in control group (p<0.01), but there was no statistical significancebetween these two groups (p>0.05). The levels of fasting plasma glucose (FPG) and blood glucose 2 h after takingglucose in hypertension plus IGT group were markedly higher than other groups (p<0.01). Homeostasis modelassessment-insulin resistance (HOMA-IR), TNF-α and CRP contents were on the progressive increase in control,hypertension and hypertension plus IGT groups, but significant differences were presented among each group(P<0.01). Hypertension accompanied by IGT had a significantly-positive association with CRP, TNF-α, FPGand blood glucose 2h after taking glucose.
Conclusions: The levels of plasma TNF-α and CPR in patients withhypertension accompanied by IGT increase significantly, indicating that inflammatory reaction in these patientincreases, thus suggesting that these patients should be focused regarding cancer prevention.