Effects of Preemptive Analgesia with Parecoxib Sodium on Haemodynamics and Plasma Stress Hormones in Surgical Patients with Thyroid Carcinoma


Background: To investigate the effects of preemptive analgesia with parecoxib sodium on haemodynamicsand plasma stress hormones in surgical patients with thyroid carcinoma. Materials and
Methods: Fifty-sevenpatients with thyroid carcinoma who underwent thyroidectomy selectively in Laiwu Hospital Affiliated to TaishanMedical University and Binzhou People’s Hospital were selected and randomly divided into three groups, 19 casesin each group. The control group was intravenously injected 0.9% sodium chloride injection before anesthesiainduction; trial group I was intravenously injected with parecoxib sodium 20 min before anesthesia induction;based on trial group I, trial group II was injected with parecoxib sodium again 12 h after surgery. The levels ofplasma norepinephrine (NE), cortisol (Cor) and blood glucose before, 12 and 24 h after surgery and changes ofhaemodynamics before surgery, at the end of surgery and 12, 24 and 48 h after surgery were compared in thethree groups. Besides, visual analogue scale (VAS) scores were recorded 4, 8, 12 and 24 h after surgery.
Results:12 and 24 h after surgery, the levels of plasma NE and Cor in three groups rose dramatically (P<0.05 or (P<0.01);The levels of plasma NE and Cor in trial groups I and II were evidently lower than in control group (P<0.05or P<0.01), and those in trial group II slightly lower than in trial group I. 12 h after surgery, the heart rates(HR) and systolic pressures (SBP) in trial groups I and II increased obviously by comparison to surgery before(P<0.05 or P<0.01), but gradually returned to the preoperative level. HR, SBP and diastolic pressures (DBP) intrial groups I and II at the end of surgery and 12 h after surgery were all lower than in the control group, andsignificant differences were present (P<0.05 or (P<0.01). At 4, 8, 12 and 24 h after surgery, VAS scores in trialgroups I and II were markedly lower than in the control group ((P<0.05 or (P<0.01), the scores in trial groupII being the lowest.
Conclusions: Combined application of parecoxib sodium for preemptive analgesia beforeanesthesia and after surgery can effectively reduce the levels of plasma stress hormones and improve analgesiceffects in surgical patients with thyroid carcinoma, and without conspicuous impact on haemodynamics.