Consanguinity Protecting Effect Against Breast Cancer among Tunisian Women: Analysis of BRCA1 Haplotypes


The purpose of this study is to assess the effect of consanguinity on breast cancer incidence in Tunisia. Weconducted a case-control study to evaluate the involvement of heterozygote and homozygote haplotypes ofBRCA1 gene SNPs according to consanguinity among 40 cases of familial breast cancer, 46 cases with sporadicbreast cancer and 34 healthy controls. We showed significant difference in consanguinity rate between breastcancer patients versus healthy controls P = 0.001. Distribution of homozygous BRCA1 haplotypes among healthywomen versus breast cancer patients was significantly different; p=0.02. Parental consanguinity seems to protectagainst breast cancer in the Tunisian population