Head and Neck Squamous Cell Carcinoma - Comparative Evaluation of Pathological Parameters in Young and Old Patients


Background: To evaluate pathological features of head and neck squamous cell carcinoma (HNSCC) and tocompare these pathological features in patients younger and older than 40 years. Materials and
Methods: Allresection specimens of HNSCC between 2010 and 2013 evaluated. Tumor characteristics - grade, location (site)cervical node status, alongwith presence or absence of extranodal extension, lymphovascular invasion, genderand age - were extracted from surgical pathology reports.
Results: Among these n=19 patients (21.8%) were40 years or younger and n=68 patients (78.2%) were above 40 years of age. The mean age was 34 (20-40 years)in the younger group and 56 (42-86) in the older group. The most common location of HNSCC in both groupswas the oral cavity. The analysis of histopathological features including grade of tumor, tumor size, extranodalextension and comparison between two groups do not show any significant difference.
Conclusions: There are nospecific pathological characteristics of HNSCC in young patients. An interesting observation is that exposure toexpected risk factors is similar in both groups, in younger patients they have less time to act and yet tumors arethe same in terms of tumor size, lymph node status and lymphovascular invasion. Therefore further research isrecommended to look for potentiating factors.