Objective: To determine the predictors of lympho-vascular space invasion (LVSI) in endometrial cancerswhich contain mucinous carcinomatous histology. Materials and Methods: Clinical and histopathological dataof endometrial carcinomas with a mucinous carcinomatous component diagnosed between January 2007 andJanuary 2014 at the Gynecologic Oncology Department of Zekai Tahir Burak Women’s Health Education andResearch Hospital were reviewed retrospectively. Results: Twelve patients (25.5%) were positive for LVSI and 35(74.5%) patients were negative. Patients with LVSI were mostly staged higher than 1A. Mean age, BMI and paritywere not significantly different between patient groups. Larger tumor diameter (≥2cm) (p=0.04) and elevatedCa125 and Ca-19.9 (p=0.01) levels were significant for predicting LVSI. We also found >1/2 myometrial invasion(p<0.001), cervical stromal involvement (p=0.002) and higher grade (2-3) (p=0.001) significant for predictingLVSI. In multivariate analysis we found only grade significant for predicting LVSI. Conclusions: Especiallygrade of tumor is a crucial factor for determining LVSI in endometrial cancers with mucinous carcinomatouscomponents.