Paraoxonase 1 (PON1) Q192R Gene Polymorphism and Cancer Risk: A Meta-Analysis Based on 30 Publications


Common genetic variation Q192R in the paraoxonase 1 (PON1) gene has been considered to be implicated inthe development of many cancers. Nevertheless, results from the related studies were inconsistent. To elucidatethe association, we performed a meta-analysis for 8,112 cases and 10,037 controls from 32 published case-controlstudies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the associationby STATA 12.0 software. Overall, we revealed that the PON1-192R allele was associated with a reduced risk of theoverall cancers. Moreover, in the stratified analysis by cancer types (breast cancer, prostate cancer, brain canceretc.), the results showed that PON1-192R allele was associated with a decreased risk in breast cancer (R vs Q:OR=0.605, 95% CI=0.378-0.967, Pheterogeneity=0.000; RR vs QQ: OR=0.494, 95% CI=0.275-0.888, Pheterogeneity=0.002;RQ vs QQ: OR=0.465, 95% CI=0.259-0.835, Pheterogeneity=0.000; and RR+RQ vs QQ: OR=0.485, 95% CI=0.274-0.857,Pheterogeneity=0.000), and associated with prostate cancer in homozygote (RR vs QQ: OR=0.475, 95% CI=0.251-0.897, Pheterogeneity=0.001) and recessive models (RR vs RQ+QQ: OR=0.379, 95% CI=0.169-0.853, Pheterogeneity=0.000),while an increased risk was identified in lymphoma (R vs Q: OR=1.537, 95% CI=1.246-1.896, Pheterogeneity=0.944;RR vs QQ: OR=2.987, 95% CI=1.861-4.795, Pheterogeneity=0.350; RR+RQ vs QQ: OR=1.354, 95% CI=1.021-1.796,Pheterogeneity=0.824; and RR vs RQ+QQ: OR=2.934, 95% CI=1.869-4.605, Pheterogeneity=0.433), and an increased risk inprostate cancer under heterozygote comparison (RQ vs QQ: OR=1.782, 95% CI=1.077-2.950, Pheterogeneity=0.000)and dominant models (RR+RQ vs QQ: OR=1.281, 95% CI=1.044-1.573, Pheterogeneity=0.056). When subgroupanalysis that performed by the control source (hospital based or population based), a decreased risk of the overallcancers was revealed by homozygote (RR vs QQ: OR=0.601, 95% CI=0.366-0.987, Pheterogeneity=0.000) and dominantmodels (RR vs RQ+QQ: OR= 0.611, 95% CI=0.384-0.973, Pheterogeneity=0.000) in hospital based group. Stratifyingby ethnicity, a significantly reduced risk of the overall cancers under allele contrast model (R vs Q: OR=0.788,95% CI=0.626-0.993, Pheterogeneity=0.000) was uncovered in Caucasian. In summary, these findings suggested thatPON1 Q192R polymorphism was associated with a reduced risk of the overall cancers, nevertheless, it mightincrease cancer susceptibility of prostate and lymphoma risk. Large well-designed epidemiological studies willbe continued on this issue of interest.