Analysis of Prethrombotic States in Patients with Malignant Tumors


Background: This study aimed to investigate the incidence and risk factors for a prethrombotic state inpatients with malignant tumors. Materials and
Methods: Plasma d-dimer (D-D) in patients with malignanttumors was measured. Abnormal rates of D-D and possible risk factors like gender, age, type of tumor, andstaging of tumor were analyzed.
Results: Of 1,453 patients, 629 demonstrated plasma D-D abnormality (43.3%).The D-D abnormal rate of male patients (n=851, 43.5%) was not statistically significantly different from that forfemale patients (n=602, 43.0%) (p>0.05). D-D abnormal rate increased with age and was statistically significantamong different age groups (p<0.05). Regarding staging of tumor, D-D abnormal rate in patients with phaseⅠwas 2.0%, 6.2% in phase Ⅱ, 47.6% in phase Ⅲ and 83.1% in phase Ⅳ, with statistically significant differencesbetween phase Ⅲ and Ⅱ, as well as phase Ⅲ and Ⅳ (p<0.01).
Conclusions: A prethrombotic state was closelyrelated to malignancy of tumors. The risk factors for a prethrombotic state include age and tumor stage.