Abstract
Background: Low-risk human papillomavirus (LR-HPV) infection is the main cause of genital warts. LRHPVgenotypes 6 and 11 are associated with genital warts, but there have only been a few published studiesabout the genotype-specific prevalence of HPV in genital warts in China. The objective of our study was toassess the prevalence of HPV genotypes for clinical cases involving both men and women and to evaluate thepotential benefit of a quadrivalent (genotypes 6, 11, 16, and 18) HPV vaccine in eastern Guangdong provinceof China. Materials and
Methods: A total of 696 eligible patients with genital warts were enrolled during theperiod Aug 2009 through Oct 2014. Specimens were collected from genital warts, the HPV GenoArray test wasused for HPV detection and genotyping, which could detect 21 HPV genotypes, including genotypes 6, 11, 16,and 18.
Results: Among the 696 cases, 675 samples were successfully genotyped. The median age of patients was32.1 years (range, 16-67 years). The most prevalent genotypes were HPV-6 (285/675, 42.2%), HPV-11 (265/675,39.3%), HPV-52 (52/675, 7.7%), HPV-16 (51/675, 7.56%), HPV-81 (50/675, 7.40%) and HPV-58 (37/675, 5.48%).Low-risk genotypes predominated, with a prevalence of 96.59%. The cumulative prevalence of genotypes 6and 11 was 78.7% (531/675), the cumulative prevalence of genotypes 16 and 18 was 11.6% (78/675), and thecumulative prevalence of genotypes 6, 11, 16, and 18 was 82.5% (557/675).
Conclusions: Our results providestrong evidence that, in eastern Guangdong, different from Western countries, the most prevalent low risk HPVgenotypes in patients with genital warts are 6, 11 and 81. The quadrivalent HPV vaccine could prevent 82.5%of genital warts in eastern Guangdong.
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