Background: Multiple myeloma (MM) is influenced by genetic and micro-environmental changes. Malignant plasma cells produce an abnormal monoclonal immunoglobulin, as well as cytokines, such as IL-10 and IL-6 which stimulate cells of the bone marrow microenvironment (BMM) and cause dysfunction and failure of many organs. B cell activating factor (BAFF), IL6 and IL10 are known to influence the growth and survival of malignant clones. Aim: The objectives of the present study were to investigate the circulating levels of BAFF , IL-10 and IL-6, correlate them with well-known parameters of disease activity in patients with MM, and to detect their impact on patients' survival. Materials and Methods: This study was conducted on 89 newly diagnosed MM patients and seventy apparently healthy volunteers as a normal control group. BAFF, IL6, IL10 were measured by ELISA for both groups and survival analysis was performed for all patients. Results: Studied markers were higher in the MM patients compared to the normal control subjects. Patients survival was improved by high serum BAFF levels. Conclusions: High levels of BAFF were found to improve patients' survival. BAFF and IL-6 can be considered probable diagnostic markers for MM.
Abdelgawad, I. A , Radwan, N. H , Shafik, R. E and Shokralla, H. A (2016). Significance of Proliferation Markers and Prognostic Factors in Egyptian Patients with Multiple Myeloma. Asian Pacific Journal of Cancer Prevention, 17(3), 1351-1355.
MLA
Abdelgawad, I. A, , Radwan, N. H, , Shafik, R. E, and Shokralla, H. A. "Significance of Proliferation Markers and Prognostic Factors in Egyptian Patients with Multiple Myeloma", Asian Pacific Journal of Cancer Prevention, 17, 3, 2016, 1351-1355.
HARVARD
Abdelgawad, I. A, Radwan, N. H, Shafik, R. E, Shokralla, H. A (2016). 'Significance of Proliferation Markers and Prognostic Factors in Egyptian Patients with Multiple Myeloma', Asian Pacific Journal of Cancer Prevention, 17(3), pp. 1351-1355.
CHICAGO
I. A Abdelgawad , N. H Radwan , R. E Shafik and H. A Shokralla, "Significance of Proliferation Markers and Prognostic Factors in Egyptian Patients with Multiple Myeloma," Asian Pacific Journal of Cancer Prevention, 17 3 (2016): 1351-1355,
VANCOUVER
Abdelgawad, I. A, Radwan, N. H, Shafik, R. E, Shokralla, H. A Significance of Proliferation Markers and Prognostic Factors in Egyptian Patients with Multiple Myeloma. Asian Pacific Journal of Cancer Prevention, 2016; 17(3): 1351-1355.
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