Evaluating the Existence of Small Compressed Binucleated Squamous Cells in ASC-H

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Department of Medical Technology, Kyorin University, Faculty of Health Sciences, 5-4-1 Shimorenjaku Mitaka,181-0013,Tokyo, Japan

Abstract

 
Purpose: To evaluate the legitimacy of a diagnosis of ASC-H in 5 cases which were followed up monthly for over 2 years with both cytology and HPV testing. Methods: Some 5 cases out of a total of 25.0 self-sampled Pap test patients diagnosed as ASC-H provided 119 specimens over 2 years, with HPV-DNA testing perormed using a E6 primer. Results: Cases 1, 2 and 3 showed SIL after the ASC-H diagnosis, while cases 4 and 5 showed and maintained NILM. Cases 1, 2 and 3 were further characterized by small atypical compressed binucleated cells, in which HPV was detected by in situ PCR. Case 4 showed a high N/C ratio in cells in sheets with a mild increase in chromatin. Case 5 demonstrated a high N/C ratio in small cells with no increase in chromatin. Conclusion: The finding of a compressed binucleated cells can define the difference between degenerated endocervical columnar cells and small atypical cells suggestive of HSIL. When small compressed binucleated squamous cells are detected, there may be a chance of continuing HPV infection and undetected SIL
Asian Pacific Journal of Cancer Prevention
Volume 17, Issue 10
October 2016
Pages 4665-4669

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History

  • Receive Date: 27 November 2016
  • Accept Date: 27 November 2016

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