Effects of Six Weeks Endurance Training and Aloe Vera Supplementation on COX-2 and VEGF Levels in Mice with Breast Cancer

Document Type : Research Articles


1 Department of Laboratory Sciences, Hyperlipidemia research center, faculty of paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz

2 Department of Physical education, Islamic Azad University, Ayatollah Amoli Branch, Amol

3 Nutrition and Metabolic Diseases Research Center Ahvaz Jundishapur, University of Medical Sciences

4 Student research committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz


The aim of this study was to determine effects of six weeks endurance training and Aloe Vera supplementation on COX-2 and VEGF levels in mice with breast cancer. For this purpose, 35 rats were randomly divided into 5 groups: control (healthy) and 4 cancer groups: control (cancer only), training, Aloe Vera and Aloe Vera + training. Breast cancer tumors were generated in mice by implantind. The training program comprised six weeks of swimming training accomplished in three sessions per week. Training time started with 10 minutes on the first day and increased to 60 minutes in the second week and the water flow rate was increased from 7 to 15 liters per minute at a constant rate. Aloe Vera extract at a dose of 300 mg/kg BW was administrated to rats by intraperitoneal injection. At the end of the study period, rats were anesthetized and blood samples were taken. Significant differences were concluded at pCOX-2 and VEGF levels in the cancer group compared with the healthy group. Administration of Aloe Vera extract caused significant decrease in the COX-2 level in the cancer group. Also, in the training (swimming exercise) and Aloe Vera + training cancer groups, we observed significant decrease in the VEGF level as compared to controls. Our results suggest that Aloe Vera and training inhibit the COX pathway and cause decrease production of prostaglandin E2. Hence administration of Aloe Vera in combination with endurance training might synergistically improve the host milieu in mice bearing breast cancers.