Background: Gastric cancer is the fifth most common cancer and the third top cause of cancer related death with about 1 million new cases and 700,000 deaths in 2012. The aim of this investigation was to identify important factors for outcome using a random survival forest (RSF) approach. Materials and Methods: Data were collected from 128 gastric cancer patients through a historical cohort study in Hamedan-Iran from 2007 to 2013. The event under consideration was death due to gastric cancer. The random survival forest model in R software was applied to determine the key factors affecting survival. Four split criteria were used to determine importance of the variables in the model including log-rank, conversation?? of events, log-rank score, and randomization. Efficiency of the model was confirmed in terms of Harrell’s concordance index. Results: The mean age of diagnosis was 63 ±12.57 and mean and median survival times were 15.2 (95%CI: 13.3, 17.0) and 12.3 (95%CI: 11.0, 13.4) months, respectively. The one-year, two-year, and three-year rates for survival were 51%, 13%, and 5%, respectively. Each RSF approach showed a slightly different ranking order. Very important covariates in nearly all the 4 RSF approaches were metastatic status, age at diagnosis and tumor size. The performance of each RSF approach was in the range of 0.2966-0.3250 and the best error rate was obtained by the log-rank splitting rule; second, third, and fourth ranks were log-rank score, conservation of events, and the random splitting rule, respectively. Conclusion: Low survival rate of gastric cancer patients is an indication of absence of a screening program for early diagnosis of the disease. Timely diagnosis in early phases increases survival and decreases mortality.
Adham, D., Abbasgholizadeh, N., & Abazari, M. (2017). Prognostic Factors for Survival in Patients with Gastric Cancer using a Random Survival Forest. Asian Pacific Journal of Cancer Prevention, 18(1), 129-134. doi: 10.22034/APJCP.2017.18.1.129
MLA
Davoud Adham; Nategh Abbasgholizadeh; Malek Abazari. "Prognostic Factors for Survival in Patients with Gastric Cancer using a Random Survival Forest". Asian Pacific Journal of Cancer Prevention, 18, 1, 2017, 129-134. doi: 10.22034/APJCP.2017.18.1.129
HARVARD
Adham, D., Abbasgholizadeh, N., Abazari, M. (2017). 'Prognostic Factors for Survival in Patients with Gastric Cancer using a Random Survival Forest', Asian Pacific Journal of Cancer Prevention, 18(1), pp. 129-134. doi: 10.22034/APJCP.2017.18.1.129
VANCOUVER
Adham, D., Abbasgholizadeh, N., Abazari, M. Prognostic Factors for Survival in Patients with Gastric Cancer using a Random Survival Forest. Asian Pacific Journal of Cancer Prevention, 2017; 18(1): 129-134. doi: 10.22034/APJCP.2017.18.1.129
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