Cisplatin-Induced Nephrotoxicity; Protective Supplements and Gender Differences

Document Type : Systematic Review and Meta-analysis


Water and Electrolytes Research Center, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran.


Cisplatin (CDDP) has been widely used as a chemotherapeutic agent for solid tumors. The most common side effect of CDDP is nephrotoxicity, and many efforts have been made in the laboratory and the clinic to employ candidate adjuvants to CDDP to minimize this adverse influence. Many synthetic and herbal antioxidants as well as trace elements have been investigated for this purpose in recent years and a variety of positive and negative results have been yielded. However, no definitive supplement has so far been proposed to prevent CDDP-induced nephrotoxicity; however, this condition is gender related and the sex hormone estrogen may protect the kidney against CDDP damage. In this review, the results of research related to the effect of different synthetic and herbal antioxidants supplements are presented and discussed with suggestions included for future work.


Main Subjects

Volume 18, Issue 2
February 2017
Pages 295-314
  • Receive Date: 06 October 2016
  • Revise Date: 09 February 2017
  • Accept Date: 09 March 2017
  • First Publish Date: 09 March 2017