Aim: Abnormal expression pattern ofBetatubulin isotypesmay provide a molecular rationalefor thebehaviour of lymphoma subtypes. The study assessed class II and III Beta-tubulin expression in non-neoplastic and neoplastic lymphoid tissues. Their differential expressions may have diagnostic implications and potential usefulness in the development of new tumour biomarkers. Methods& results: This cross-sectional study investigated class II and III Beta-tubulin expression in 304 neoplastic and 20 normal lymphoid tissues using qualitatively and semi-quantitatively immunohistochemistry. Class II Beta-tubulin was expressed in the germinal centre, mantle zone and interfollicular region of normal lymphoid tissues. Class III Beta-tubulin expression however was germinal centre restricted. Among lymphomas, Class II Beta-tubulin was expressed in 15/15 (100%) lymphoblastic lymphomas, 229/231 (99%) mature B cell lymphomas, 22/22 (100%) T/NK-cell lymphomas and 36/36(100%) classical Hodgkin lymphomas. Class III Beta-tubulin expression however was more selective, found mainly in classical Hodgkin lymphomas (34/36 (94%)). It was also expressed in 58/171(34%) DLBCL, 11/12 (92%) mantle cell lymphomas and 6/6 (100%) Burkitt lymphomas. Other mature B cell, T/NK cell lymphomas and precursor lymphoblastic lymphomas were usually negative. Conclusion:Class II Beta-tubulin shows ubiquitous expression in the neoplastic and non-neoplastic lymphoisd tissues. In contrast, Class III Beta-tubulin expression is germinal centre-restricted. Its consistent expression in classical Hodgkin lymphoma is useful in the identification of Reed-Sternberg and Hodgkin cells. Its expression in a proportion of DLBCL, Burkitt and mantle cell lymphomas is of interest as this may be related to their aggressiveness.
Binti Yusof, N. S. , ameli, F. , Sabrina Florence, C. , Mustangin, M. , Abd-Rahman, F. and Masir, N. (2017). Expression of the Class II and III Beta-tubulin in neoplastic and non-neoplastic lymphoid tissues.. Asian Pacific Journal of Cancer Prevention, 18(4), 1045-1050. doi: 10.22034/APJCP.2017.18.4.1045
MLA
Binti Yusof, N. S. , , ameli, F. , , Sabrina Florence, C. , , Mustangin, M. , , Abd-Rahman, F. , and Masir, N. . "Expression of the Class II and III Beta-tubulin in neoplastic and non-neoplastic lymphoid tissues.", Asian Pacific Journal of Cancer Prevention, 18, 4, 2017, 1045-1050. doi: 10.22034/APJCP.2017.18.4.1045
HARVARD
Binti Yusof, N. S., ameli, F., Sabrina Florence, C., Mustangin, M., Abd-Rahman, F., Masir, N. (2017). 'Expression of the Class II and III Beta-tubulin in neoplastic and non-neoplastic lymphoid tissues.', Asian Pacific Journal of Cancer Prevention, 18(4), pp. 1045-1050. doi: 10.22034/APJCP.2017.18.4.1045
CHICAGO
N. S. Binti Yusof , F. ameli , C. Sabrina Florence , M. Mustangin , F. Abd-Rahman and N. Masir, "Expression of the Class II and III Beta-tubulin in neoplastic and non-neoplastic lymphoid tissues.," Asian Pacific Journal of Cancer Prevention, 18 4 (2017): 1045-1050, doi: 10.22034/APJCP.2017.18.4.1045
VANCOUVER
Binti Yusof, N. S., ameli, F., Sabrina Florence, C., Mustangin, M., Abd-Rahman, F., Masir, N. Expression of the Class II and III Beta-tubulin in neoplastic and non-neoplastic lymphoid tissues.. Asian Pacific Journal of Cancer Prevention, 2017; 18(4): 1045-1050. doi: 10.22034/APJCP.2017.18.4.1045
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