Therapeutic Potential of Novel Nano-Based Curcumin Compounds In Vitro and In Vivo

Document Type : Systematic Review and Meta-analysis


Department of Biology, School of Natural Sciences, University of Tabriz, Tabriz, Iran.


Despite recent advances in cancer medication, malignant tumors continue to be the second leading cause of death
worldwide. Furthermore, introducing a therapeutic compound with low-side effects as well as low-price for consumers
is controversial. Recent efforts have been focusing on traditional medicines as a rich source of herbal agents. Curcumin,
the major turmeric phytochemical, has been widely assessed as an anti-cancer compound in vitro and in vivo. However,
the use of curcumin in cancer treatment has limitations because of its low solubility, poor tissue absorption, rapid
metabolism and rapid systemic elimination. Recent work has focused on improving the stability of curcumin to facilitate
clinical application. Dendrosomal nano-corcumin (DNC) is one of the most successful compounds showing significant
cellular absorption and also anti-tumor effects. The present overview of newest applicable strategies for curcumin-based
therapy and their clinical potential usefulness has the emphasis on DNC.


Main Subjects