Association between Polymorphisms of ERCC5 Gene and Susceptibility to Gastric Cancer: A Systematic Review and Meta-Analysis

Document Type : Systematic Review and Meta-analysis


1 Department of Internal Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

2 Department of Emergency Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

3 Department of Restorative and Esthetic, Arak University of Medical Sciences, Arak, Iran.

4 Department of Endodontic, Arak university of Medical Sciences, Arak, Iran.

5 Department of Pediatric Dentistry, Arak university of Medical Sciences, Arak, Iran.

6 Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


Background: several epidemiological studies have suggested that polymorphisms of the Excision Repair Cross Complementing Group-5 (ERCC5) gene might be related to gastric cancer risk; however, the results have been inconsistent or controversial. Therefore, we have performed a systematic review and meta-analysis to clarify the association between the ERCC5 gene polymorphisms and gastric cancer risk. Materials and Methods: An electronic search was conducted of several databases, including PubMed, Web of Science, and Google Scholar for articles that describe the association between polymorphisms of the ERCC5 gene and susceptibility of gastric cancer. Results: A total of 33 case control studies in 15 publications were included in the present meta-analysis. There were significant associations between gastric cancer susceptibility and ERCC5 gene rs751402 C>T (T vs. C: OR = 1.166, 95% C = 1.066-1.274, p= 0.001; TT vs. CC: OR = 0.723, 95% CI = 0.587-0.890, p = 0.002; TT+TC vs. CC: OR = 0.853, 95% CI = 0.757-0.961, p = 0.009; TT vs. TC+CC: OR = 0.793, 95% CI = 0.659-0.955, p = 0.015), rs2296147 T>C (C vs. T: OR = 1.268, 95% C = 1.049-1.532, p= 0.014), rs873601 G>A polymorphisms (A vs. G, OR = 1.087, 95% C = 1.021-1.159, p= 0.010; AA vs. GG, OR = 1.184, 95% CI = 1.043-1.343, p = 0.009, AA vs. AG+GG, OR = 1.156, 95% CI = 1.040-1.284, p = 0.007), but not rs2094258 C>T and rs1047768 T>C. Conclusion: the current meta-analysis demonstrates that rs751402 C>T, rs2296147 T>C, and rs873601 G>A polymorphisms of ERCC5 gene are associated with the susceptibility of gastric cancer.


Main Subjects

Volume 18, Issue 10
October 2017
Pages 2611-2617
  • Receive Date: 18 June 2017
  • Revise Date: 13 July 2017
  • Accept Date: 14 October 2017
  • First Publish Date: 14 October 2017