Molecular Subtypes, Apoptosis and Proliferation Status in Indonesian Diffuse Large B-Cell Lymphoma Cases

Document Type : Research Articles

Authors

1 Department of Anatomical Pathology, Faculty of Medicine, Universitas Gadjah Mada/Sardjito Hospital, Yogyakarta, Indonesia.

2 Division of Hematology Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Gadjah Mada/Sardjito Hospital, Yogyakarta, Indonesia

3 Department of Anatomy, Faculty of Medicine, Universitas Gadjah Mada/Sardjito Hospital, Yogyakarta, Indonesia.

Abstract

 
Objective: The diffuse large B-cell lymphoma (DLBCL) has two major molecular subtypes, germinal center B-cell-like (GCB) and non-GCB. These have differing behavior which affects overall patient survival. However, immunohistochemistry based molecular subtyping of Indonesian DLBCLs has been limited. This was the focus of the present study, with a focus of attention on the apoptotic index (AI) and the proliferation index (PI) of the two molecular subtypes. Materials and Methods: During the study period of 3.5 years, a total of 98 cases of DLBCL were identified. Molecular subtypes and PI were determined by immunohistochemistry and TUNEL method was used to determine the AI. Result: GCB accounted for 31 cases (31.6%) and non-GCB the remainder (68.4%). Gender showed a slight male predominance (54 cases, 55.1%), with a higher incidence in the extra-nodal region (57 cases, 58.2%). The AI and PI were significantly higher in GCB (pConclusion: The findings indicate that the non-GCB subtype is more common than GCB in Indonesian DLBCL. GCB features significantly higher PI and AI, which themselves appear linked.

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Asian Pacific Journal of Cancer Prevention
Volume 19, Issue 1
January 2018
Pages 185-191

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History

  • Receive Date: 24 September 2017
  • Revise Date: 24 November 2017
  • Accept Date: 23 December 2017

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