The Complementary Role of Imaging and Tumor Biomarkers in Gynecological Cancers: An Update of the Literature

Document Type : Systematic Review and Meta-analysis


1 Department of Molecular Medicine, Sapienza University, Viale Regina Elena 324, 00161 Roma, Italy.

2 Department of Radiology, Sapienza University, Viale Regina Elena 324, 00161 Roma, Italy.


Gynecological tumors, including endometrial, cervical and ovarian cancer, have increased in incidence over
time. The widespread introduction of screening programs and advances in diagnostic imaging methods has lead to a
progressive increase in gynecological cancer detection. Accurate diagnosis and proper monitoring of disease remain
the primary target for a successful treatment. In the last years, knowledge about cancer biomarkers has considerably
increased providing great opportunities for improving cancer detection and treatment. In addition, in the last few years
there has been an important development of imaging techniques. Nowadays, a multimodal approach including the
evaluation of serum tumor biomarkers combined with imaging techniques, seems to be the best strategy for assessing
tumor presence, spread, recurrence, and/or the response to treatment in female cancer patients In this review we provide
an overview of the application of biomarkers combined with novel imaging methods and highlight their roles in female
cancer diagnosis and follow-up.


Main Subjects