Risk Factors, Biomarkers, Etiology, Outcome and Prognosis of Ischemic Stroke in Cancer Patients

Document Type : Research Articles


Ankara University School of Medicine, İbni Sina Hospital, Department of Neurology, Samanpazarı, Ankara Turkey.


Introduction: Cerebrovascular disease is the second most common complication in individuals with tumours.
The aim of this study was to investigate risk factors, biomarkers, etiology and prognosis of ischemic stroke in cancer
patients (ISCPs). Methods: The medical records of 619 consecutive patients who were admitted with acute ischemic
stroke from January 2012 to November 2014 were retrospectively evaluated. The patients were divided into two groups
(group 1, patients with an active cancer prior to the onset of ischemic stroke; group 2, patients without an active cancer
history). The demographic data, risk factors, NIHSS scores, thrombocyte count, D-dimer, fibrinogen and C reactive
protein (CRP) level at admission, modified Rankin Scale (mRS) scores in the follow-up period and location of lesions
on DWI were recorded. The Mann-Whitney U test, chi-squared test and logistic regression was used for analyzing data,
pwas significantly lower in the ISCP group (p=0.001). Elevated thrombocyte counts, D-dimer, fibrinogen and CRP levels
at admission, acute multiple ischemic lesions, other causes, mortality in hospital and worse outcome were significantly
related to ISCP (p<0.05). On logistic regression analysis, follow up mRS>3, acute multiple ischemic lesions located
in more than one vascular territory (AMIMCT) and other causes were significantly associated with ISCP (p<0.001).
Conclusion: In our study, other causes, AMIMCT and mRS>3 were more common in the ISCP group. We consider that
CCS could be more suitable for detecting other causes than TOAST. Biomarkers could be important in the ISCP group.


Main Subjects