Diagnostic Yield of Transbronchial Biopsy in Comparison to High Resolution Computerized Tomography in Sarcoidosis Cases

Document Type : Research Articles


1 Department of Pulmonary Medicine , Medical Faculty, Gazi University, Ankara, Turkey.

2 Ankara Ataturk Training and Research Hospital, Ankara, Turkey.


This study aimed to evaluate the diagnostic yield of fiberoptic bronchoscopic (FOB) transbronchial biopsy and
its relation with quantitative findings of high resolution computerized tomography (HRCT). A total of 83 patients,
19 males and 64 females with a mean age of 45.1 years diagnosed with sarcoidosis with complete records of high
resolution computerized tomography were retrospectively recruited during the time period from Feb 2005 to Jan 2015.
High resolution computerized tomography scans were retrospectively assessed in random order by an experienced
observer without knowledge of the bronchoscopic results or lung function tests. According to the radiological staging
with HRCT, 2.4% of the patients (n=2) were stage 0, 19.3% (n=16) were stage 1, 72.3% (n=60) were stage 2 and 6.0%
(n=5) were stage 3. This study showed that transbronchial lung biopsy showed positive results in 39.7% of the stage I
or II sarcoidosis patients who were diagnosed by bronchoscopy. Different high resolution computerized tomography
patterns and different scores of involvement did make a difference in the diagnostic accuracy of transbronchial biopsy


Main Subjects