Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer

Dolatkhah, Roya; Somi, Mohammad Hossein; Shabanloei, Reza; Farassati, Faris; Fakhari, Ali; Dastgiri, Saeed

doi:10.22034/APJCP.2018.19.8.2183

Main Risk Factors Association with Proto-Oncogene Mutations in Colorectal Cancer

Document Type : Research Articles

Authors

¹ Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

² Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

³ Department of Medical- Surgical Nursing, Nursing and Midwifery Faculty, Tabriz University of Medical Sciences, Tabriz, Iran.

⁴ The University of Kansas Medical School-Molecular Medicine Laboratory, Kansas City, KS, USA.

⁵ Research Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.

⁶ Tabriz Health Services Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

10.22034/APJCP.2018.19.8.2183

Abstract

Objective: Although several factors have been shown to have etiological roles in colorectal cancer, few investigations
have addressed how and to what extent these factors affect the genetics and pathology of the disease. Precise relationships
with specific genetic mutations that could alter signaling pathways involved in colorectal cancer remain unknown.
We therefore aimed to investigate possible links between lifestyle, dietary habits, and socioeconomic factors and specific
mutations that are common in colorectal cancers. Methods: Data were retrieved from a baseline survey of lifestyle factors,
dietary behavior, and SES, as well as anthropometric evaluations during a physical examination, for 100 confirmed
primary sporadic colorectal cancer patients from Northwest Iran. Results: High socioeconomic status was significantly
associated with higher likelihood of a KRAS gene mutation (P < 0.05) (odds ratio: 3.01; 95% CI: 0.69–13.02). Consuming
carbohydrates and alcohol, working less, and having a sedentary lifestyle also increased the odds of having a KRAS
mutation. Conclusion: Although research has not yet described the exact relationships among genetic mutations with
different known risk factors in colorectal cancer, examples of the latter may have an impact on KRAS gene mutations.

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