Abstract: Gastric cancer is one of the most common upper gastrointestinal malignancies. Some Iranian provinces, such as in the northern and northwestern areas, are at a high risk, whereas the central and western provinces are at a medium and the southern regions at low risk. This study was carried out to estimate the impact of the expression patterns of ASIC1 and IL-6 genes and the IL-6rs-174 and ASIC1rs 75624685 polymorphisms in the pathogenesis of gastric cancer. Materials and methods: Tetra-ARMS PCR was employed to analyze the polymorphism status of the ASIC1 and IL-6 genes with 85 paraffin-embedded tissue blocks from cases and 117 normal blood samples as controls. We also investigated mRNA expression levels of these genes in 12 cases and controls using real-time PCR. Results: Our results showed a significant association between expression of ASIC1 and elevated risk of gastric cancer (p<0.001).
Heydari-Mehrabadi, A. , Kordi-Tamandani, D. M. , Baranzehi, T. and Hemati, S. (2018). Analysis of Polymorphism and Expression Profile of ASIC1 and IL-6 Genes in Patients with Gastric Cancer. Asian Pacific Journal of Cancer Prevention, 19(12), 3451-3455. doi: 10.31557/APJCP.2018.19.12.3451
MLA
Heydari-Mehrabadi, A. , , Kordi-Tamandani, D. M. , , Baranzehi, T. , and Hemati, S. . "Analysis of Polymorphism and Expression Profile of ASIC1 and IL-6 Genes in Patients with Gastric Cancer", Asian Pacific Journal of Cancer Prevention, 19, 12, 2018, 3451-3455. doi: 10.31557/APJCP.2018.19.12.3451
HARVARD
Heydari-Mehrabadi, A., Kordi-Tamandani, D. M., Baranzehi, T., Hemati, S. (2018). 'Analysis of Polymorphism and Expression Profile of ASIC1 and IL-6 Genes in Patients with Gastric Cancer', Asian Pacific Journal of Cancer Prevention, 19(12), pp. 3451-3455. doi: 10.31557/APJCP.2018.19.12.3451
CHICAGO
A. Heydari-Mehrabadi , D. M. Kordi-Tamandani , T. Baranzehi and S. Hemati, "Analysis of Polymorphism and Expression Profile of ASIC1 and IL-6 Genes in Patients with Gastric Cancer," Asian Pacific Journal of Cancer Prevention, 19 12 (2018): 3451-3455, doi: 10.31557/APJCP.2018.19.12.3451
VANCOUVER
Heydari-Mehrabadi, A., Kordi-Tamandani, D. M., Baranzehi, T., Hemati, S. Analysis of Polymorphism and Expression Profile of ASIC1 and IL-6 Genes in Patients with Gastric Cancer. Asian Pacific Journal of Cancer Prevention, 2018; 19(12): 3451-3455. doi: 10.31557/APJCP.2018.19.12.3451